The canine copper toxicosis locus is not syntenic with ATP7B or ATX1 and maps to a region showing homology to human 2p21
نویسندگان
چکیده
منابع مشابه
a comparison of teachers and supervisors, with respect to teacher efficacy and reflection
supervisors play an undeniable role in training teachers, before starting their professional experience by preparing them, at the initial years of their teaching by checking their work within the proper framework, and later on during their teaching by assessing their progress. but surprisingly, exploring their attributes, professional demands, and qualifications has remained a neglected theme i...
15 صفحه اولThe mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region.
The Delta Sxrb deletion interval of the mouse Y chromosome contains Spy, a spermatogenesis factor gene(s) whose expression is essential for the postnatal development of the mitotic germ cells, spermatogonia. The boundaries of Delta Sxrb are defined by the duplicated genes Zfy1 and Zfy2 and four further genes have previously been mapped within the interval: Ube1y and Smcy, linked with Zfy1 on a ...
متن کاملUse of 64copper measurements to diagnose canine copper toxicosis.
Inherited canine copper toxicosis is a serious problem in Bedlington terriers and West Highland White terriers, and may also be a problem in other less-studied breeds. Affected dogs become ill at midlife with progressive and ultimately fatal liver disease. Treatments for removal of copper and prevention of copper accumulation are available, but are most effective if begun before the dog becomes...
متن کاملit is not possible to understand developments of a country’s culture and civilization without knowing his believes and myths. whether it is north or south, east or west, planes or mountains, sahara or deserts, here in iran every corner includes valuable and precious treasures which are known all over the world, and cultural – historical objects which are found here adorn all well known museums of the globe. zagros mountains, lorestan province locating at the heart of that, are not only the same, but are more prominent than other iranian regions. you can not find someone who does not know what the lorestani bronzes are, and there is no museum that not be pride of having a piece of that. the said bronzes which are manufactured four millenniums b.c. are admired nearly by all those researchers because of their beauty, diversity and technique. lorestani artistic works including stone engraves, bronzes and clays, show an ideal and metaphysical world beside real world which explain mental system of human beings on that era against sensations and phenomena happening around them. men main mental occupation on that time was he unknown world which had surrounded them, and they used to use the religion to fight life’s natural factors, and art was a tool of religious and mythical painting which was far from reality and had entered into the abstract domain. as natural objects have become subjects of lorestani art, it cleanses them from any non – intrinsic limitations and external factors which surround them and darken their meanings, and just shows their main specifications. artist in the said civilization is not searching for realism. although these are few works showing the nature, but in effect there is no wish to imitate touchable factors of the nature, and artist has turned real phenomena to encoded signs as per his own mentality. this procedure is called stylization.
it is not possible to understand developments of a country’s culture and civilization without knowing his believes and myths. whether it is north or south, east or west, planes or mountains, sahara or deserts, here in iran every corner includes valuable and precious treasures which are known all over the world, and cultural – historical objects which are found here adorn all well known museums...
Copper binding to the N-terminal metal-binding sites or the CPC motif is not essential for copper-induced trafficking of the human Wilson protein (ATP7B).
The Wilson protein (ATP7B) is a copper-translocating P-type ATPase that mediates the excretion of excess copper from hepatocytes into bile. Excess copper causes the protein to traffic from the TGN (trans-Golgi network) to subapical vesicles. Using site-directed mutagenesis, mutations known or predicted to abrogate catalytic activity (copper translocation) were introduced into ATP7B and the effe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Mammalian Genome
سال: 1999
ISSN: 0938-8990,1432-1777
DOI: 10.1007/s003359901085